Antibody | Days after ulcer induction | Mucosa (ulcer margin) | Submusoca (ulcer base) |
α1 (I) procollagen | 3 | + | +++ |
5 | ++ | +++ | |
7 | ++ | +++ | |
12 | ++ | +++ | |
15 | ++ | +++ | |
30 | ++ | +++ | |
α1 (III) procollagen | 3 | − | + |
5 | − | + | |
7 | + | ++ | |
12 | + | ++ | |
15 | + | ++ | |
30 | + | ++ | |
α1 (IV) procollagen | 3 | + | + |
5 | + | + | |
7 | +(+) | ++ | |
12 | +(+) | ++ | |
15 | +(+) | ++ | |
30 | +(+) | ++ |
−, +, ++, and +++ indicate the relative intensity of APAAP staining with individual primary antibodies during the healing process in ulcerated tissue compared with controls.