Pretreatment metronidazole sensitivity and eradication of H pylori
| Treatment group | ||||
|---|---|---|---|---|
| LAC | LAM | LCM | OAM | |
| Pretreatment metronidazole sensitivity | ||||
| Intention to treat5-150 | ||||
| Resistant (%) | 39 (38.2) | 41 (37.6) | 28 (27.2) | 32 (32.7) |
| Sensitive (%) | 63 (61.8) | 68 (62.4) | 75 (72.8) | 66 (67.3) |
| Per protocol | ||||
| Resistant (%) | 39 (39.0) | 39 (38.2) | 25 (25.5) | 28 (30.4) |
| Sensitive (%) | 62 (61.0) | 63 (61.8) | 73 (74.5) | 64 (69.6) |
| Eradication by metronidazole sensitivity | ||||
| Intention to treat5-150 | ||||
| Resistant (%) | 36/39 (92.3) | 19/41 (46.3) | 21/28 (75.0) | 20/32 (62.5) |
| (95% CI) | (78.0, 98.0) | (31.0, 62.4) | (54.8, 88.6) | (43.7, 78.3) |
| Sensitive (%) | 55/63 (87.3) | 60/68 (88.2) | 71/75 (94.7) | 62/66 (93.9) |
| (95% CI) | (76.0, 94.0) | (77.6, 94.4) | (86.2, 98.3) | (84.4, 98.0) |
| Per protocol | ||||
| Resistant (%) | 36/39 (92.3) | 18/39 (46.2) | 19/25 (76.0) | 19/28 (67.9) |
| (95% CI) | (78.0, 98.0) | (30.4, 62.6) | (54.5, 89.8) | (47.6, 83.4) |
| Sensitive (%) | 54/61 (88.5) | 57/63 (90.5) | 69/73 (94.5) | 60/64 (93.8) |
| (95% CI) | (77.2, 94.9) | (79.8, 96.1) | (85.8, 98.2) | (84.0, 98.0) |
↵5-150 This is based on those patients in the intention to treat population (n = 496) who had returned for a visit 3 breath test (n = 465) minus those patients (n = 53) who had no pretreatment metronidazole sensitivity reported (n = 412).