Effect of alosetron on diarrhoea, loperamide use, stool weight, and stool fat on completion of the study
| Dose of alosetron (twice daily) | |||
|---|---|---|---|
| 0.1 mg | 0.5 mg | 2.0 mg | |
| No (%) of patients with 20% improvement in diarrhoea score | 4 (50) | 2 (22) | 3 (33) |
| Median (range) diarrhoea score, last week of treatment | 4.0 (1.5–7.3) | 3.5 (0.7–6.6) | 2.5 (0.0–4.4) |
| Median (range) no of loperamide tablets used over 3 weeks of treatment | 21 (0–60) | 4 (0–14) | 4 (0–6) |
| n=7 | n=7 | n=5 | |
| Stool weight (g) | 453 (87) | 359 (110) | 264 (42) |
| Stool fat (g) | 5.9 (2.1) | 5.8 (1.4) | 4.3 (1.0) |
| Percentage fat in stool | 15.4 (3.4) | 18.4 (3.5) | 11.9 (1.7) |
p=NS for all parameters.