Hepatic iron staining in patients with fibrotic alcoholic liver disease and different HFE genotypes
| Number with hepatocyte iron grade (%) | |||||
| HFE genotype | 0 | 1 | 2 | 3 | Total |
| Wild type homozygote | 19 (83) | 0 (0) | 3 (13) | 1 (4) | 23 (100) |
| H63D heterozygote | 19 (73) | 3 (12) | 3 (12) | 1 (4) | 26 (100) |
| H63D homozygote | 4 (67) | 0 (0) | 2 (33) | 0 (0) | 6 (100) |
| C282Y heterozygote | 14 (61) | 3 (13) | 4 (17) | 2 (9) | 23 (100) |
| C282Y, H63D heterozygote | 1 (20) | 0 (0) | 2 (40) | 2 (40) | 5 (100) |
| C282Y homozygote | 0 (0) | 1 (33) | 0 (0) | 2 (67) | 3 (100) |
Wild type homozygotes were selected to match the C282Y heterozygotes for sex and age (±3 years). Grade 1 iron, barely discernible at low power magnitude; grade 2, discrete granules seen at medium power; grade 3, discrete granules seen at low power; grade 4, masses visible at low power.