Other parameters
| Time (hours) | ||||||
|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | |
| Haemoglobin (g/l) | ||||||
| Control | 120 (5) | 139 (7) | 126 (8) | 131 (7) | 123 (6) | 125 (5) |
| Bosentan | 107 (7) | 130 (6) | 118 (5) | 108 (4) | 106 (4) | 108 (6)* |
| pH arterial blood | ||||||
| Control | 7.39 (0.02) | 7.29 (0.02) | 7.23 (0.04) | 7.17 (0.05) | 7.16 (0.04) | 7.19 (0.04) |
| Bosentan | 7.39 (0.02) | 7.35 (0.02) | 7.23 (0.03) | 7.22 (0.03) | 7.25 (0.02) | 7.27 (0.02) |
| Base excess (mmol/l) | ||||||
| Control | −1.4 (1.0) | −6.3 (1.2) | −10.9 (2.2) | −13.3 (2.1) | −13.0 (2.0) | −12.5 (1.8) |
| Bosentan | −2.2 (1.2) | −5.3 (0.7) | −9.7 (1.4) | −9.8 (1.4) | −8.9 (1.3) | −8.7 (1.1)* |
| Pco 2arterial blood (kPa) | ||||||
| Control | 5.1 (0.2) | 5.6 (0.4) | 5.2 (0.2) | 5.4 (0.3) | 5.7 (0.2) | 5.4 (0.1) |
| Bosentan | 5.0 (0.2) | 4.9 (0.2) | 5.5 (0.1) | 5.8 (0.2) | 5.6 (0.1) | 5.3 (0.1) |
| Renal blood flow index (ml/kg/min) | ||||||
| Control | 4.9 (0.4) | 3.2 (0.5) | 2.7 (0.9) | 2.3 (0.7) | 3.1 (0.8) | 3.6 (1.2) |
| Bosentan | 5.5 (0.8) | 4.6 (0.7) | 3.4 (0.8) | 3.5 (0.9) | 3.8 (1.0) | 3.7 (1.0) |
| Endothelin-1-like immunoreactivity in arterial plasma (pmol/l) | ||||||
| Control | 15.2 (3.0) | 29.4 (2.8) | 42.8 (3.6) | 65.7 (15.2) | 59.1 (12.9) | 52.0 (11.9) |
| Bosentan | 14.5 (1.2) | 27.5 (2.2) | 36.7 (2.5) | 194 (19.0) | 185 (18.9) | 180 (29.9)*** |
| Endothelin-1-like immunoreactivity in portal venous plasma (pmol/l) | ||||||
| Control | 17.0 (2.5) | 24.5 (2.1) | 47.3 (4.3) | 44.9 (3.9) | 60.0 (12.1) | 61.1 (13.3) |
| Bosentan | 18.3 (1.8) | 30.1 (3.2) | 43.1 (4.4) | 207 (32.5) | 163 (16.9) | 184 (25.1)*** |
Data are presented as mean (SEM). *p<0.05; ***p<0.001.