Polymorphism at CTLA-4 exon 1 position 49 in patients with coeliac disease and controls
| Nucleotide at position 49 (codon at position 17) | Coeliac disease (n=101) | Controls (n=130) | Odds ratio (95% CI) |
| Phenotype frequencies | |||
| A positive (Thr) | 97 (96.0) | 109 (83.8) | 4.67 (1.54–14.09)1-150 |
| G positive (Ala) | 32 (31.7) | 68 (52.3) | 0.42 (0.24–0.72)1-150 |
| Genotype frequencies1-151 | |||
| AA (Thr/Thr) | 69 (68.3) | 62 (47.7) | 2.36 (1.37–4.06)1-152 |
| AG (Thr/Ala) | 28 (27.7) | 47 (36.2) | |
| GG (Ala/Ala) | 4 (4.0) | 21 (16.2) | 0.21 (0.07–0.64)1-152 |
| Allele frequencies1-153 | |||
| A (Thr) | 166 (82.2) | 171 (65.8) | |
| G (Ala) | 36 (17.8) | 89 (34.2) |
Results are expressed as number (%).
↵1-150 p values of odds ratios defined by Fisher’s exact test (A phenotype), or χ2 test (1 DF) using a 2×2 contingency table (G phenotype); p=0.0027 for both.
↵1-151 χ2 test of heterogeneity (2 DF) using a 3×2 contingency table; p= 0.0013.
↵1-152 p values of odds ratio for GG and AA genotypes; p= 0.0027 for both.
↵1-153 χ2 test of heterogeneity (1 DF) using a 2×2 contingency table; p< 0.0001.