Release of TNF and inhibitors in the isolated cell culture study
| Measured cytokine | Normal controls LPMCs (n=10) | Involved LPMCs | Non-involved LPMCs | ||||||
| CD (n=16) | UC (n=18) | CD (n=16) | UC (n=10) | ||||||
| TNF-α | 21.5 (15–79) | 385 (95–745)7-150 † | 725 (158–1278)7-150 † | 64.0 (38–74) | 48.0 (20–127) | ||||
| TNF-β | 25.0 (18–26) | 20.5 (16–24) | 32.0 (22–41) | 30.5 (25–32) | 30.0 (28–34) | ||||
| sTNF-R1 | 533 (450–578) | 475 (245–700) | 450 (220–600) | 550 (425–590) | 500 (208–320) | ||||
| sTNF-R2 | 200 (180–410) | 545 (345–1525) | 500 (200–1300) | 750 (340–1520) | 250 (200–320) | ||||
Cytokine levels and soluble receptors levels are given as pg/mg tissue wet weight, and all data are presented as median (interquartile range) adjusted to 100 000 cells/well.
↵7-150 p<0.01 v controls; †p<0.01v non-involved LPMCs.
UC, ulcerative colitis; CD, Crohn’s disease.