Outcomes | Botulinum toxin | Placebo | RBI (95% CI) | NNT (CI) |
Healed fissure at 1 mo | 53% | 13% | 300% (20 to 1415) | 3 (2 to 17) |
Healed fissure at 2 mo | 73% | 13% | 450% (79 to 1913) | 2 (1 to 4) |
Symptomatic relief at 1 mo | 87% | 27% | 225% (56 to 708) | 2 (1 to 4) |
Symptomatic relief at 2 mo | 87% | 27% | 225% (56 to 708) | 2 (1 to 4) |
↵1-1-150 RBI=the proportional increase in rates of good events between the botulinum toxin and placebo groups; NNT=the number of patients who must receive botulinum toxin to achieve 1 additional good outcome.