Characteristics of cell contraction induced by cholecystokinin (CCK) and acetylcholine on intestinal smooth muscle cells of guinea pig: comparison between saline and trinitrobenzenesulphonic acid (TNB) treated animals
| CCK 8 | Acetylcholine | ||||||
|---|---|---|---|---|---|---|---|
| Maximal contraction | Cmax(nM) | EC50(pM) | Maximal contraction | Cmax(nM) | EC50 (pM) | ||
| Fresh cells | 21.9 (1.8) | 10 | 20 (1.3) | 23.9 (2.7) | 1000 | 1.4 (0.5) | |
| Saline | 23.0 (2.5) | 10 | 5.0 (0.6) | 26.3 (2.2) | 1000 | 1.0 (0.3) | |
| TNB Day 1 | 14.7 (2.3) | 10 | 10.0 (1.4) | 15.1 (1.8) | 1000 | 1.0 (0.5) | |
| TNB Day 2 | 15.5 (2.6) | 10 | 7.2 (1.5) | 15.5 (2.4) | 1000 | 1.3 (0.8) | |
| TNB Day 3 | 16.3 (3.1) | 10 | 5.0 (1.2) | 14.0 (3.2) | 1000 | 2.0 (1.2) | |
| TNB Day 4 | 15.7 (2.8) | 10 | 10.2 (1.4) | 15.8 (1.8) | 1000 | 1.1 (0.4) | |
| TNB Day 6 | 15.9 (1.7) | 10 | 10.1 (1.4) | 15.5 (2.9) | 1000 | 1.0 (0.8) | |
| TNB Day 10 | 17.4 (2.7) | 10 | 5.8 (1.3) | 18.6 (3.2) | 1000 | 1.3 (0.5) | |
| TNB Day 15 | 17.8 (2.6) | 10 | 7.1 (1.5) | 18.9 (2.1) | 1000 | 1.4 (0.8) | |
Where applicable, values are mean (SEM) (n=5).