Table 1

Effect of omeprazole, ranitidine, and pyrilamine on pentagastrin induced gastroprotection against acidified aspirin injury

Pretreatment	Vehicle	Vehicle	Vehicle	Vehicle	OMP	Ranitidine	Pyrilamine
Intravenous treatment	Saline	Pentagastrin	Saline	Pentagastrin	Pentagastrin	Pentagastrin	Pentagastrin
A-ASA	−	−	+	+	+	+	+
Macroscopic injury score [n]	0.5 (0.5) [4]	1.3 (0.7) [3]	33.8 (6.3) [8]	7.3 (3.5)^1-150 [6]	17.8 (3.9)^1-150[6]	45.7 (8.6)^† ^‡ ^§ [6]	6.8 (2.9)^1-150 [5]
Histological injury score [n]		21.6 (12.0) [3]	156.5 (12.0) [8]	56.5 (9.1)^1-150 [6]	88.3 (20.8)^1-150 [6]	152.8 (16.8)^† ^‡ ^§[6]	90.5 (16.6)^1-150 [5]
% Surface injury		9.1 (5.0)	10.2 (2.3)	12.1 (1.4)	17.6 (4.9)	10.0 (2.5)^‡	11.6 (3.1)
% Shallow injury		6.3 (3.5)	42.7 (4.8)	19.8 (4.5)^1-150	12.3 (7.0)^1-150	26.3 (5.3)^1-150	14.8 (4.7)^1-150
% Deep injury		0.0 (0.0)	21.3 (5.5)	3.2 (1.9)^1-150	8.0 (2.7)	29.8 (7.3)^† ^‡	16.4 (4.3)^†

Values expressed as mean (SEM) obtained from the number of rats indicated in square brackets.
↵1-150 p<0.05 v vehicle + saline + A-ASA, ^†p<0.05 v vehicle + pentagastrin + A-ASA,^‡ p<0.05 v OMP + pentagastrin + A-ASA, ^§p<0.05 v pyrilamine + pentagastrin + A-ASA among five groups treated with A-ASA.
OMP, omeprazole.