Table 1

Intestinal inflammation in Lewis rats two and 14 days after subcutaneous injection with buffer or indomethacin

	No of rats	Gross gut score	No of ulcers in small bowel	Percentage of surface area ulcerated	Histological inflammatory score	IL-1β (pg/mg tissue)
Acute phase (2 days)
Indomethacin	13	4.1 (0.58)^***	14.3 (1.4)^***	26.4 (6)^1-160	3.7 (0.3)^***	21.3 (5.0)^1-160
Control	8	0	0	0	0.1 (0.03)^1-151	5.3 (1.9)^§
Chronic phase (14 days)
Indomethacin	8	10.3 (1.0)^***	7.0 (1.2)^***	36 (7.7)^1-160	4.5 (0.7)^***	46.2 (11.4)
Control	7	0	0	0	0.2 (0.1)^‡	0.2 (0.03)^‡

Results are expressed as mean (SEM).
↵1-160 p<0.01, ^***p⩽0.001.
↵1-151 Performed on six indomethacin and four buffer treated rats;^‡performed on five indomethacin and four buffer treated rats;^§performed on six indomethacin and seven buffer treated rats.