T cell subsets and degree of activation in inflamed and non-inflamed pouch and ileal mucosa
| UC with pouchitis | UC without pouchitis | FAP without pouchitis | ||||||
|---|---|---|---|---|---|---|---|---|
| Pouch (n=8) | Ileum (n=5) | Pouch (n=10) | Ileum (n=7) | Pouch (n=9) | Ileum (n=3) | |||
| CD3+/CD4+ | 45.4 (36.9–71.1) | 23.4 (18.0–25.9) | 30.2 (9.1–45.3) | 20.5 (20.1–39.9) | 35.3 (30.9–66.7) | 44.2 (24.8–52.9) | ||
| CD3+/CD8+ | 42.5 (25.4–57.4) | 62.5 (59.3–72.6) | 54.8 (35.6–82.0) | 72.0 (46.9–80.8) | 48.9 (22.7–57.1) | 42.9 (30.6–51.7) | ||
| CD4:CD8 ratio | 1.3 (0.7–2.7)3-150 | 0.4 (0.3–0.4) | 0.6 (0.1–1.0) | 0.3 (0.2–0.8) | 0.9 (0.5–2.9) | 1.0 (0.5–1.7) | ||
| CD4+/CD25+ | 16.0 (8.6–20.8)† | 7.7 (4.0–12.0) | 11.9 (3.2–20.4) | 3.3 (1.1–8.7) | 9.3 (2.0–17.8) | 3.1 (2.8–7.0) | ||
| CD8+/CD25+ | 8.6 (2.2–16.5) | 7.1 (2.4–12.0) | 7.4 (1.1–48.7) | 2.0 (1.8–3.8) | 4.5 (0.0–14.2) | 3.5 (2.4–4.6) | ||
| CD4+/HLA-DR+ | 10.7 (6.8–34.6) | 7.9 (3.6–10.3) | 12.3 (1.2–28.9) | 8.2 (4.8–12.4) | 17.9 (6.8–33.6) | 10.5 (6.2–22.5) | ||
| CD8+/HLA-DR+ | 19.9 (11.2–31.5)‡ | 2.1 (1.6–5.7) | 11.3 (3.6–38.5) | 5.1 (2.1–16.2) | 12.5 (1.9–42.1) | 4.3 (2.0–34.4) | ||
↵3-150 p=0.012, †p=0.036, ‡p=0.05.