Table 3

Intestinal inflammation in patients on long term NSAIDs

No studied No abnormal 4 day faecal excretion of 111In white cells (% dose)
Normal controls2200.5  (0.2)%
Patient controls2030.6 (0.3)%
Indomethacin52304.1 (2.9)%5-150
Piroxicam28153.9 (1.1)%5-150
Naproxen58423.9 (0.8)%5-150
Ibuprofen29163.0 (1.2)%5-150
Flurbiprofen1694.5 (3.2)%5-150
Ketoprofen1493.5 (1.8)%5-150
Diclofenac38244.4 (4.8)%5-150
Aspirin710.7 (0.3)%
Sulindac952.5 (1.9)%5-150
Etodolac1173.7 (2.1)%5-150
Fenbufen1162.7 (2.3)%5-150
Nabumetone1321.1 (0.4)%
  • Values represent mean (SD) faecal excretion of111Indium labelled neutrophils (% dose) following intravenous instillation.

  • 5-150 Differs significantly (ANOVA) from normal and patient controls, p<0.05.