Interferon γ (IFN-γ) release in culture supernatants of both unstimulated and phytohaemagglutinin (PHA) preactivated lamina propria T lymphocytes (T-LPLs) and autologous peripheral blood T lymphocytes (T-PBLs) after 24 hours of exposure to graded doses of interleukin 12 (IL-12)
| IFN-γ secretion (pg/ml) | |||||
|---|---|---|---|---|---|
| Unstimulated lymphocytes | PHA activated lymphocytes | ||||
| T-LPLs | T-PBLs | T-LPLs | T-PBLs | ||
| Medium alone | 0 | 0 | 16 (4.1) | 23 (3.0) | |
| IL-12 (pg/ml) | |||||
| 10 | 14 (2.9) | 0 | 46 (2.5) | 48 (5.0) | |
| 100 | 18 (1.2) | 0 | 65 (6.0) | 74 (6.0) | |
| 1000 | 24 (2.0) | 18 (2.8) | 190 (10) | 260 (10) | |
Results are expressed as mean (SD) from six representative experiments.