Histological changes in caerulein induced pancreatitis with or without IL-10 blockade
| Time after starting caerulein injection | Acute pancreatitis + IL-10 monoclonal antibody | Acute pancreatitis + control monoclonal antibody |
| 4 hours (n = 10) | ||
| Oedema | 1.6 (0.5) | 1.4 (0.5) |
| Inflammation | 2.2 (0.4)3-150 | 1.6 (0.5)3-150 |
| Necrosis | 2.3 (0.5)3-150 | 1.6 (0.6)3-150 |
| Global score | 6.1 (0.5)3-150 | 4.8 (0.8)3-150 |
| 6 hours (n = 8) | ||
| Oedema | 2.5 (0.7)3-150 | 1.8 (0.6)3-150 |
| Inflammation | 2.8 (0.4)3-150 | 2.0 (0.4)3-150 |
| Necrosis | 2.9 (0.4)3-150 | 2.1 (0.6)3-150 |
| Global score | 8.1± 1.1)** | 5.9 (1.1)** |
| 8 hours (n = 8) | ||
| Oedema | 2.0 (0) | 1.6 (0.5) |
| Inflammation | 2.4 (0.4)** | 1.6 (0.5)** |
| Necrosis | 1.8 (0.4) | 2.0 (0.4) |
| Global score | 6.2 (0.8) | 5.2 (1.0) |
| 15 hours (n = 10) | ||
| Oedema | 1.3 (0.2) | 1.1 (0.5) |
| Inflammation | 1.8 (0.4) | 1.4 (0.4) |
| Necrosis | 0.8 (0.4) | 0.6 (0.2) |
| Global score | 3.9 (1.0) | 3.1 (1.1) |
Each animal was graded histologically once and then a mean (SD) score was calculated for each parameter in each group. The global score is the combined blind histological score of the three parameters.
↵3-150 p < 0.05; **p < 0.01.