Amsterdam criteria |
Histologically verified colorectal cancer in three relatives, one a first degree relative of the other two |
One colorectal cancer diagnosed before the age of 50 years |
Two or more generations affected |
Familial adenomatous polyposis excluded |
Less strict criteria for HNPCC |
Colorectal cancer in two first degree relatives |
One colorectal cancer diagnosed before the age of 50 years |
Consistent with dominant inheritance |
Familial adenomatous polyposis excluded |
Plus at least one of: |
A third colorectal cancer |
Endometrial cancer, small bowel cancer, ureteric cancer |
Early onset (aged less than 50 years) ovarian, stomach, bladder, or hepatobiliary carcinoma |
A third relative under 45 years of age with an adenoma or significant polyp (>1 cm, tubulovillous or villous, or with severe dysplasia) at any age |
From Hall et al.8