Table 1

Clinical characteristics of individual family members

Subject no	Age (y)	Sex	Gene status	Examination type	Age at examination	Number of colon polyps	Colon cancer (Y/N)	Age at cancer diagnosis	Extracolonic manifestations
Family 1
I:2	79	F	NK	Colonoscopy	74	>100	N	N/A	NK
II:1	54	F	−	Sigmoidoscopy	54	0	N	N/A	None
II:2	53	M	+	Colonoscopy	48	>100	Y	48	None
II:5	52	F	+	Colonoscopy	46	6	N	N/A	Lipomas, gastric polyps^1-150
II:6	50	F	+	Colonoscopy	44	4	N	N/A	Gastric polyps^1-150
III:1	24	M	NK	Sigmoidoscopy	21	0	N	N/A	NK
III:2	23	F	+	Sigmoidoscopy	22	0	N	N/A	None
III:3	29	M	+	Sigmoidoscopy	29	1	N	N/A	Lipomas
III:4	28	M	+	Sigmoidoscopy	27	0	N	N/A	Lipomas
III:5	25	F	−	Sigmoidoscopy	24	0	N	N/A	None
Family 2
I:2	N/A	F	NK	NK	NK	NK	Y	46	NK
II:1	60	M	+	Colonoscopy	51	>100	N	N/A	Osteoma, adrenal tumour, gastric and duodenal polyps^1-150
III:1	34	M	+	Colonoscopy	33	6	N	N/A	Sebaceous cysts
III:2	32	F	NK	Colonoscopy	28	>100	N	N/A	Gastric polyps, desmoid tumours, osteomas^1-150
III:3	29	F	NK	Colonoscopy	25	>100	N	N/A	Desmoid tumours, sebaceous cysts
III:4	19	M	+	Colonoscopy	18	0	N	N/A	None
Family 3
I:1	NK	M	NK	NK	NK	NK	Y	NK	Pancreatic cancer
II:1	51	M	+	Colonoscopy	50	>100	N	N/A	None^1-150
III:1	18	M	NK	None	N/A	N/A	N	N/A	NK
III:2	14	M	NK	None	N/A	N/A	N	N/A	NK
I:1	58	M	NK	None	N/A	NK	N	N/A	Liver or bladder cancer
II:2	68	F	+	Colonoscopy	51	>100	N	N/A	Osteomas, fibrosarcoma, lipoma, desmoids, duodenal polyps^1-150
II:3	67	M	NK	Colectomy	60	>100	Y	60	Osteoma, bladder cancer
II:5	73	M	NK	Colectomy	59	>100	N	N/A	None
II:6	71	M	NK	Sigmoidoscopy	54	0	N	N/A	None
III:1	47	M	NK	None	N/A	N/A	Y	46	Epidermoid cysts, desmoids, cancer-multiple primaries
III:2	45	F	NK	Colonoscopy	36	>100	N	N/A	Desmoid^1-150
III:3	39	M	NK	Sigmoidoscopy	23	0	N	N/A	None
III:4	35	M	NK	Sigmoidoscopy	19	0	N	N/A	None
III:5	41	F	NK	Colonoscopy	40	0	N	N/A	Jaw lesion, hepatoma, desmoid^1-150
III:6	50	F	NK	Colonoscopy	33	0	N	N/A	Jaw lesion

↵1-150 Upper endoscopy performed.
NK, not known; N/A, not applicable.