Effect of oestradiol on type I collagen production in cultured rat hepatic stellate cells
| Addition | Dose (M) | Day | Type I collagen production (μg/ml) |
| Oestradiol | 0 | 5 | 35 (6) (100%) |
| 10−8 | 5 | 32 (5) (91%) | |
| 10−7 | 5 | 29 (4) (82%) | |
| 10−6 | 5 | 25 (4) (71%)3-150 | |
| Oestradiol | 0 | 10 | 64 (7) (100%) |
| 10−8 | 10 | 56 (7) (88%) | |
| 10−7 | 10 | 51 (5) (80%)3-150 | |
| 10−6 | 10 | 43 (5) (67%)3-150 |
Values are expressed as mean (SD) (%) for four dishes.
Cells cultured for two days were further incubated in the presence or absence of oestradiol (10−8–10−6) for three days (day 5) or eight days (day 10).
↵3-150 p<0.05 versus controls for the same culture period.