Table 1

Summary of study groups, route of drug administration, dose and schedule of caerulein challenges

Experimental group Dose, route of administration Time before caerulein stimulation
Control (vehicle)i.v./i.p.–
l-NAME30 mg/kg, i.v.2 min
l-NAME 2530 mg/kg, i.v.25 min
Indazole50 + 50 mg/kg, i.p.50 and 2 min
Indazole 100100 mg/kg, i.p.2 min
Systemic capsaicin150 mg/kg, s.c.5 days
Local capsaicin0.1%, perivagal + 1% intraduodenal5 days
Caerulein alone0.1–50 μg/kg, i.v.–
Haemoglobin500 + 500 mg/kg, i.v.2 min
Aminoguanidine40 mg/kg, i.v.60 and 2 min

  • i.v., intravenous; i.p., intraperitoneal; s.c., subcutaneous.