HFE genotypes and sex corrected mean serum iron indexes for the study population
| Genotype | No of subjects (n=1064) | Frequency (%) | Serum iron concentration (μmol/l) | Total iron binding capacity (μmol/l) | Transferrin saturation (%) | Serum ferritin concentration (μg/l) |
| C282Y homozygous | 5 | 0.5 | 34.3*** (5.4) | 41.3*** (4.6) | 83.4***(14.4) | 397.2** (179.8–875.9) |
| Compound heterozygosity | 19 | 1.8 | 21.4** (4.5) | 51.8*** (7.7) | 42.0***(9.3) | 127.3 (84.5–191.3) |
| H63D homozygous | 24 | 2.3 | 21.2**(6.4) | 54.4** (10.0) | 39.3*** (11.3) | 107.5 (74.7–154.6) |
| C282Y heterozygous | 121 | 11.4 | 18.7† (5.7) | 55.1***(8.1) | 34.7*** (12.1) | 93.0 (79.0–109.3) |
| H63D heterozygous | 240 | 22.6 | 18.8** (6.6) | 57.53-150 (9.4) | 33.4***(12.8) | 90.7 (80.8–101.7) |
| Normal (no HFEmutation) | 655 | 61.6 | 17.7 (5.7) | 59.1 (9.5) | 30.5 (10.2) | 86.9 (81.0–93.2) |
Results expressed as mean (SD) except for serum ferritin concentrations which are expressed as the geometric mean (95% confidence intervals).
↵3-150 p<0.05, **p<0.01, ***p<0.001, †p=0.051.