Clinical and biochemical characteristics and markers of bone metabolism in patients with alcoholic cirrhosis and controls
| Cirrhotic patients (n=15) | Controls (n=20) | |
|---|---|---|
| Patient characteristics | ||
| Height (cm) | 176 (159–184)1-152 | 168 (155–185) |
| Weight (kg) | 74.0 (50.0–95.3) | 68.5 (38.5–105.0) |
| Body mass index (kg/m2) | 22.0 (17.7–30.8) | 24.4 (16.0–35.1) |
| Age (years) | 59 (38–69) | 55 (30–78) |
| Child class (A/B/C) | 3/6/6 | NA |
| Ascites (Yes/no) | 11/4 | 0/20 |
| Hepatic venous pressure gradient (mm Hg; <5)1-150 | 18.0 (7.0–26.0)§ | 3.0 (2.0–5.0) |
| Hepatic blood flow (l/min; 0.5–2.3)1-150 | 0.83 (0.35–1.61) | 1.13 (0.90–1.45) |
| ICG clearance (l/min; 0.30–0.70)1-150 | 0.18 (0.02–0.45)§ | 0.42 (0.37–0.61) |
| Blood biochemistry | ||
| Serum aspartate aminotransferase (U/l; 10–40)1-150 | 67 (14–430)1-152 | 22 (14–52) |
| Serum bilirubin (μmol/l; 2–17)1-150 | 21 (5–01)1-152 | 7 (5–20) |
| Serum alkaline phosphatase (U/l; 50–275)1-150 | 329 (132–1065)1-152 | 194 (106–242) |
| Plasma coagulation factors 2, 7, and 10 (units; 0.70–1.30)1-150 | 0.71 (0.23–0.99)1-152 | 1.18 (0.40–1.30)1-151 |
| Serum albumin (μmol/l; 540–800)1-150 | 466 (348–671)§ | 624 (501–698) |
| Serum creatinine (μmol/l; 49–121)1-150 | 79 (54–293) | 82 (54–204) |
| Serum sodium (mmol/l; 136–146)1-150 | 133 (123–142)§ | 140 (134–144) |
| Carbohydrate deficient transferrin (U/l; females: 0–26 U/l; males: 0–20 U/l)1-150 | 19.5 (6.0–32.0)1-152 | 12.0 (6.0–27.0) |
| Bone metabolism | ||
| Parathyroid hormone (ng/ml; 10–65)1-150 | 48 (11–111) | 58 (23–155) |
| Serum calcium (mmol/l; 2.14–2.57)1-150 | 2.25 (2.05–2.42) | 2.13 (2.00–2.36) |
| Serum calcium, albumin adjusted (mmol/l; 2.13–2.49)1-150 | 2.37 (2.29–2.48)1-152 | 2.27 (2.12–2.37) |
| Osteocalcin (μg/l; 3–19)1-150 | 7.6 (4.4–33.8)1-152 | 12.8 (5–34) |
| 25-hydroxyvitamin D (μg/l; 15–41)1-150 | 8.5 (7.0–18.0)1-152 | 16.5 (6.0–37.0) |
| 1,25-dihydroxyvitamin D (ng/l; 17–43)1-150 | 11.5 (6.0–31.0)1-152 | 19.5 (8.0–59.0) |
Results are expressed as median (total range).
↵1-150 Reference intervals in parentheses.
↵1-151 One individual in the control group had plasma coagulation factors of 0.40 arbitrary units, due to treatment with
anticoagulants for an iliofemoral artery prosthesis.
↵1-152 p<0.05, §p<0.005 compared with controls.
NA, not applicable.