Table 1

Effects of different anti-inflammatory drugs on lipopolysaccharide (LPS) induced P-selectin expression in pancreas, stomach, heart, and skeletal muscle

LPS
TreatmentControlUntreated5-ASADEXMTX6-MP
Pancreas12 (1)84 (7)66 (6)47 (6)1-150 81 (5) 82 (9)
Stomach20 (3)75 (8)47 (7)33 (7)1-150 54 (6) 74 (7)
Heart 7 (1)94 (11)56 (7)56 (7)74 (10)111 (13)
Muscle10 (3)31 (3)25 (2)20 (3)16 (1) 22 (2)
  • Results are expressed as mean (SEM) in ng monoclonal antibody/g tissue.

  • 1-150 p<0.05 v LPS + untreated.

  • 5-ASA, 5-aminosalicylic acid; DEX, dexamethasone; MTX, methotrexate; 6-MP, 6-mercaptopurine.