Table 2

Effects of different anti-inflammatory drugs on lipopolysaccharide (LPS) induced E-selectin expression in pancreas, stomach, heart, and skeletal muscle

LPS
TreatmentControlUntreated5-ASADEXMTX6-MP
Pancreas2 (1)38 (2)22 (2)3-150 20 (2)3-150 34 (2)33 (3)
Stomach3 (1)36 (1)23 (3)25 (2)36 (4)38 (5)
Heart5 (2)70 (5)38 (6)3-150 32 (5)3-150 79 (10)86 (8)
Muscle1 (0)21 (1)   9 (2)3-150  7 (0)3-150 16 (2)28 (2)
  • Results are expressed as mean (SEM) in ng monoclonal antibody/g tissue.

  • 3-150 p<0.05 v LPS + untreated.

  • 5-ASA, 5-aminosalicylic acid; DEX, dexamethasone; MTX, methotrexate; 6-MP, 6-mercaptopurine.