Effect of NOS inhibition (l-NAME,l-NMA and 7-nitroindazole) and the NO precursorl-arginine on basal chloride and sodium movement
| Control | l-NAME (60 mg/kg) | l-NMA (50 mg/kg) | 7-nitroindazole (100 mg/kg) | l-arginine (1 g/kg) | d-arginine (1 g/kg) | PES + 20 mmol/ll-arginine | PES + 20 mmol/ll-NAME | |
| Number | 15 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| Chloride (μmol/min/g) | 2.5 (1.7/5.7) | 4.4 (2.6/6.5) | 2.4 (−0.4/2.9) | 4.7 (3.3/6.0) | −0.8 (−2.7/5.2) | 2.0 (0.6/2.4) | −3.81-150 (−8.5/0.9) | −5.61-150 (−9/−4.6) |
| Sodium (μmol/min/g) | 16.7 (12/19) | 16.0 (11/19) | 13.4 (10/16) | 15.6 (14/17) | 14.0 (12/16) | 14.8 (7/21) | 0.51-150 (−4/8) | −1.51-150(−3/−1) |
Data are expressed as median (interquartile ranges) in μmol/min/g dry weight.
↵1-150 p<0.004 versus controls (Kruskal-Wallis).