Table 3

Effects of different anti-inflammatory drugs on lipopolysaccharide (LPS) induced intercellular adhesion molecule 1 (ICAM-1) expression in pancreas, stomach, heart, and skeletal muscle

LPS
TreatmentControlUntreated5-ASADEXMTX6-MP
Pancreas543  (14)1186  (39)1267  (42)834  (130)5-150 1232  (91)1215  (45)
Stomach446 (29)957 (43)958 (31)688 (119)949 (91)946 (80)
Heart1256 (71)3462 (178)3200 (212)2147 (507)3164 (389)3235 (247)
Muscle259 (12)573 (38)614 (30)376 (53)569 (72)619 (27)
  • Results are expressed as mean (SEM) in ng monoclonal antibody/g tissue.

  • 5-150 p<0.05 v LPS + untreated.

  • 5-ASA, 5-aminosalicylic acid; DEX, dexamethasone; MTX, methotrexate; 6-MP, 6-mercaptopurine.