Prevalence of genetic alterations in patients and adenomas
| Alteration | Percentage of patients2-150 (fraction) | Percentage of adenomas (fraction) |
|---|---|---|
| K-rasmutation | 65 (39/60) | 35 (70/200)2-151 |
| Positive p53 immunohistochemistry | 17 (10/60) | 6 (13/201) |
| Loss of 18q | 8 (4/53) | 2 (4/176)2-152 |
| RER positivity | 15 (8/53) | 7 (13/176) |
| HNPCC | 66 (2/3) | 44 (4/9)2-153 |
| Non-HNPCC | 12 (6/50) | 5 (9/167) |
| TGFβRII mutation | 2 (1/60) | 0.5 (1/201) |
↵2-150 Number of patients who have genetic alteration in an adenoma divided by total number of patients with a specimen analysed.
↵2-151 K-ras mutation was not analysed in an adenoma due to non-amplification of DNA.
↵2-152 p=0.05 versus p53 overexpression in adenomas.
↵2-153 p=0.002 versus RER positive adenomas in non-HNPCC patients.