Clinical and investigative features at presentation
| PHVA | Surgical shunting | Significance | |
|---|---|---|---|
| (n=21) | (n=15) | (p value) | |
| Age1 | 31 (16–65) | 36 (20–57) | NS2 |
| Duration of history, months1 | 3 (0–84) | 3 (0–204) | NS2 |
| Clinical features4 | |||
| Ascites | 18 | 15 | NS3 |
| Variceal haemorrhage | 4 | 3 | NS3 |
| Hepatic encephalopathy5 | 5 | 8 | NS3 |
| Muscle wasting6 | 7 | 6 | NS3 |
| Radiological features4 | |||
| Short length hepatic vein stenosis | 21 | 4 | |
| IVC occlusion | 3 | 2 | |
| Laboratory findings1, 7 | |||
| Serum bilirubin (μM/l) | 31 (6–179) | 60 (20–255) | p<0.012 |
| Serum AST (U/l) | 48 (12–2410) | 69 (23–504) | NS2 |
| Serum albumin (g/l) | 34 (20–45) | 32 (26–39) | NS2 |
| Serum creatinine (μM/l)8 | 87 (47–247) | 104 (61–522) | |
| Prothrombin INR | 1.4 (1.0–2.9) | 1.4 (1.2–3.2) | NS2 |
| Histological features1, 9 | |||
| Centrilobular necrosis score | 1 (1–3) | 2 (0–3) | p<0.052 |
| Fibrosis score | 2 (0–3) | 1 (0–3) | NS2 |
1Median values (range given in brackets).
2Mann-Whitney U test; 3Fisher’s exact test. p values ⩾0.05 are denoted as not significant (NS).
4Absolute numbers.
5Clinical grade 1 or higher.
6Defined where clinically obvious.
7Normal laboratory values: bilirubin, 1–22 μM/l; AST, 5–43 U/l; albumin, 34–51 g/l; creatinine, 60–100 μM/l.
8Two patients in shunt group treated with haemodialysis prior to surgery.
9Centrilobular necrosis and fibrosis scores: 0=none; 1=mild; 2=moderate; 3=severe.
AST, aspartate aminotransferase.