Group | Normal | Minimal | Erosive | Barrett’s oesophagus/stricture |
---|---|---|---|---|
Primary bile acids | ||||
Cholic acid | 0 (0–8) | 0 (0–99)1-150 | 34 (0–150)1-150 | 25 (0–126)1-150 |
Taurocholic acid | 0 (0–8) | 7 (0–67)1-150 | 21 (0–198)1-150 | 39 (4–131)† |
Glycocholic acid | 0 (0–6) | 7 (0–102)1-150 | 21 (0–88)1-150 | 27 (0–95)1-150 |
Secondary bile acids | ||||
Deoxycholic acid | 0 (0–3) | 0 (0–7) | 2 (0–230)† | 0 (0–282)† |
Taurodeoxycholic acid | 0 (0–0) | 0 (0–0) | 0 (0–157)† | 5.5 (0–410)† |
Glycodeoxycholic acid | 0 (0–0) | 0 (0–47) | 2.5 (0–285)1-150 | 0 (0–72) |
Taurolithocholic acid | 0 (0–0) | 0 (0–0) | 0 (0–0) | 6 (0–482)‡ |
Total bile acid concentration | 0 (0–16) | 14 (0–257)1-150 | 124 (6–1020)† | 181 (30–820)† |
Oesophageal pH | ||||
% time pH<4 | 2.1 (0.9–12.1) | 2.7 (1.3–5.9) | 5.1 (3.6–12.1) | 22.3 (10.0–46.0)‡ |
DeMeester acid score | 11.1 (7.5–25.6) | 12.5 (8.8–20.4) | 20.2 (13.7–36.0)‡ | 43.3 (30.6–83.0)† |
↵1-150 p<0.05 versus normal; †p<0.05 versus normal and minimal;‡p<0.05 versus normal, minimal, and erosive (Mann-Whitney U test).
0 = less than the limit of sensitivity (0.25 μmol/l).