Table 3

Patients with abnormal liver blood tests or scans at follow up

Case no	Drug	Follow up after drug withdrawal (y)	LFTs	Scans^5-150	Initial histology	Follow up histology
4	Halothane	19.5	Normal	Abnormal	AH	–
7	Diclofenac	2.5	Normal	Abnormal	CH	–
8	Diclofenac	5.7	Abnormal	Normal	CH	Mild inflammation
9	Buprenorphine	1.7	Abnormal	Abnormal	CH, steatosis	Steatosis
12	Rifampicin	5	Normal	Abnormal	CH, fibrosis	–
13	Tetracycline	3.2	Abnormal	Abnormal	CH, fibrosis	CH, fibrosis
14	Nitrofurantoin	11.9	Normal	Abnormal	CH, cirrhosis	–
16	Sulpiride	1.3	Abnormal	Abnormal	CH	–
18	Methyldopa	7.9	Abnormal	Abnormal	CH	CH
19	Amiodorone	3.6	Abnormal	Abnormal	CH, fibrosis	–
21	Co-amoxiclav	1.8	Abnormal	Normal	Cholestasis, ductopenia	Ductopenia
24	Co-amoxiclav	3.4	Normal	Abnormal	Cholestasis	–
31	Phenytoin	2.5	Abnormal	Abnormal	Cholestasis, fibrosis	–

↵5-150 Isotope and ultrasound (at least one of the following three features was regarded as abnormal: uneven uptake on isotope scan; shrunken liver on ultrasound scan; or hepatomegaly with irregular texture on ultrasound scan).
LFTs, liver function tests; CH, chronic hepatitis; AH, acute hepatitis.