Table 2

Usual and unusual bile acids in meconium of newborns from patients with intrahepatic cholestasis of pregnancy

	Control	Non-UDCA	UDCA
Usual bile acids (μmol/g)
Total	1.13 (0.34)	9.96 (4.37)^*	7.17 (2.11)^†
Unusual bile acids (μmol/g)
3β,7α-Dihydroxy-5β-cholanoic	0.03 (0.01)	0.19 (0.06)^*	0.12 (0.04)^†
3α,6α-Dihydroxy-5β-cholanoic (hyodeoxycholic)	0.04 (0.01)	0.22 (0.06)^*	0.15 (0.04)^†
12α-Hydroxy-3-oxo-5β-cholanoic	0.02 (0.01)	0.35 (0.13)^*	0.18 (0.04)^††
3α,7α,12α-Trihydroxy-5β-homocholanoic	0.01 (0.01)	0.07 (0.02)^*	0.05 (0.01)^† ^, ^††
3α,6α,7α-Trihydroxy-5β-cholanoic (hyocholic)	0.30 (0.06)	0.62 (0.18)	0.51 (0.21)
3α,7α,12α-Trihydroxy-5α-cholanoic (allo-cholic)	0.09 (0.03)	0.59 (0.24)	0.29 (0.10)
7α,12α-Dihydroxy-3-oxo-4-cholenoic	0.03 (0.02)	0.16 (0.06)	0.06 (0.01)
3α-Hydroxy-7-oxo-5β-cholanoic	0.02 (0.01)	0.14 (0.04)^*	0.05 (0.01)^†
12α-Hydroxy-3,5,7-choltrienoic	0.01 (0.01)	0.09 (0.03)^*	0.03 (0.01)
2β,3α,7α,12α-Tetrahydroxy-5β-cholanoic	0.02 (0.01)	0.08 (0.02)	0.03 (0.01)
3α,12α-Dihydroxy-7-oxo-5β-cholanoic	0.04 (0.02)	0.16 (0.04)^*	0.13 (0.05)
Others	0.25 (0.01)	0.84 (0.29)^*	0.44 (0.10)
Total	0.86 (0.21)	3.52 (1.24)^*	2.04 (0.57)^†
Proportion of unusual bile acids	45.9 (3.4)	32.2 (5.0)	27.2 (6.1)^†

Concentrations of total usual and individual unusual bile acids, and proportion of unusual species in meconium of newborns from normal pregnancies (control; n=8), and from pregnancies complicated with intrahepatic cholestasis of pregnancy receiving classic palliative therapy (non-UDCA group; n=7) or treated with ursodeoxycholic acid (UDCA) until labour (UDCA group; n=9). Values are expressed as mean (SEM). ^*p<0.05, non-UDCA vcontrol;^†p<0.05 and^††p<0.01, UDCA vcontrol.