Histology in patients with normal and abnormal results on 24 hour pH monitoring
| Biopsy location | 24 h pH results | ||
|---|---|---|---|
| Normal (n=14) | Abnormal (n=16) | ||
| Z-line | |||
| Columnar mucosa | |||
| Carditis score | 4.3 (0.5) | 3.4 (0.5) | |
| Neutrophils | 57% | 18% | |
| Mononuclear cells | 64% | 16% | |
| Columnar “blues” | 38% | 44% | |
| Goblet cells | 23% | 50% | |
| Surface epithelial abnormalities | 14% | 9% | |
| Pit epithelial abnormalities | 100% | 91% | |
| Squamous mucosa | |||
| Neutrophils | 7% | 8% | |
| Eosinophils | 21% | 16% | |
| 1–2 cm below Z-line | |||
| Carditis score | 0.9 (0.5) | 0.6 (0.3) | |
Carditis scores were similar in biopsy specimens with squamous and columnar mucosa and those 1–2 cm below the Z-line in the normal and abnormal pH groups. The prevalence of neutrophils, eosinophils, mononuclear cells, goblet cells, alcian blue positive columnar cells (columnar “blues”), and epithelial changes was similar in patients with normal and abnormal 24 hour pH studies.