Normal physiological conditions
|
Salivary glands | Weak expression | Trace amount | Abundant mRNA expression (Devine et al, unpublished data) |
Oesophagus | Absent | Absent | Unknown |
Stomach | All regions; mucous cells from neck upward | Fundus, mucous neck cells; antrum, mucous cells in base of glands (surface cells mRNA only) | Absent |
Small intestine | Ductal luminal cells of Brunner’s glands | Brunner’s gland acini and distal duct and secreted mucus | Brunner’s gland acini and ducts; goblet cells |
Large intestine | Goblet cells near the surface of crypts | Absent | Goblet cells |
Gall bladder | Patchy epithelial expression | Patchy epithelial expression | Patchy epithelial expression |
Pathological conditions |
Oesophagus | Barrett’s oesophagus | Barrett’s oesophagus | Patchy mRNA expression in an rat model; not known in humans |
Stomach | Intestinal metaplasia | Mucous neck cell hyperplasia | Glands adjacent to ulceration |
Incomplete, goblet and columnar cells | Pseudopyloric metaplasia/spasmolytic peptide expressing cell lineage (SPEM) | Intestinal metaplasia |
|
Complete, goblet cells only | | |
Hyperplastic polyps | | |
Carcinoma: diffuse>intestinal | | |
Small intestine | Gastric metaplasia | Gastric metaplasia | Gastric metaplasia |
UACL upper duct and surface cells, adjacent normal cell lineages | UACL acinar cells and lower duct, adjacent cells as TFF1 | UACL acinar cells and lower duct |
Endocrine, goblet and ulcer base | Ulcer base | |
Large intestine | UACL but rarely seen | UACL but rarely seen | UACL but rarely seen |
Hyperplastic polyps | Hyperplastic polyps (mRNA only) | Hyperplastic polyps (mRNA only) |
Adenoma | Adenoma | Adenoma |
Adenocarcinoma | Adenocarcinoma | Adenocarcinoma (particularly the mucinous type) |
Gall bladder | Carcinoma of the biliary tracts | Unknown | Unknown |