Renal haemodynamics and urinary sodium excretion according to the severity of cirrhosis (Pugh’s classification, grade A, B, or C)
| Grade | |||
|---|---|---|---|
| A | B | C | |
| PAH clearance (ml/min) | 550 (63) | 479 (28) | 517 (49) |
| PAH extraction (%) | 78 (3) | 81 (2) | 79 (2) |
| Renal blood flow (litres/min) | 1.12 (0.12) | 0.91 (0.05) | 0.95 (0.06) |
| Glomerular filtration rate (ml/min) | 103 (8) | 95 (5) | 99 (8) |
| Filtration fraction (%) | 15 (1) | 17 (1) | 17 (1) |
| Renal perfusion pressure (mm Hg) | 77 (3) | 70 (2)3-150 | 64 (2)3-150 3-151 |
| Inferior vena caval pressure (mm Hg) | 8.6 (1.0) | 10.7 (1.0) | 11.4 (1.1) |
| Renal vascular resistance (dyn.s/cm5) | 6171 (873) | 7317 (662) | 6180 (418) |
| Urinary sodium excretion (μmol/min) | 38 (10) | 24 (7)3-150 | 19 (9)3-150 3-151 |
| <43-152 | |||
Results are expressed as mean (SEM).
PAH, p-aminohippurate.
↵3-150 Significantly different from corresponding values in grade A patients.
↵3-151 Significantly different from corresponding values in grade B patients.
↵3-152 Patients (n = 13) in whom urinary sodium was not detectable (lower than 5 mmol/l).