Adverse events in two or more subjects during treatment with prucalopride
| Placebo | Prucalopride | ||||
|---|---|---|---|---|---|
| 0.5 mg | 1 mg | 2 mg | 4 mg | ||
| (n=9) | (n=11) | (n=9) | (n=11) | (n=10) | |
| Diarrhoea | 2 | 3 | 8 | 6 | 8 |
| Constipation | 1 | 0 | 0 | 0 | 1 |
| Flatulence | 3 | 2 | 1 | 6 | 4 |
| Nausea | 0 | 0 | 1 | 1 | 5 |
| Abdominal pain | 1 | 1 | 3 | 4 | 3 |
| Headaches | 3 | 3 | 6 | 6 | 4 |
| Menstrual disorder3-150 | 0 | 0 | 0 | 2 | 1 |
| Dizziness | 0 | 0 | 1 | 1 | 0 |
| Skeletal pain | 0 | 1 | 0 | 1 | 0 |
| ECG nodal arrhythmia | 0 | 0 | 0 | 1 | 1 |
| Total no of subjects with adverse events | 5 | 8 | 9 | 9 | 9 |
↵3-150 Breakthrough menstrual bleeding or reduced blood loss on day 1 of menstruation.