Table 1

Animal weight, portal pressure, total serum bilirubin and serum liver enzymes after sham laparotomy (SL), portal hypertension (PH), and common bile duct ligation (CBDL) in untreated and tungsten supplemented (T) animals

SLPHCBDLSL+TPH+TCBDL+T
Weight (g)
 At the start130 (10)140 (10)145 (10)140 (10)135 (10)140 (10)
 After 4 weeks350 (120)330 (10)330 (20)340 (15)315 (20)295 (20)
Bilirubin (mg/%)0.23 (0.1)0.22 (0.2)15.1 (2.7)1-150 0.3 (0.1)0.37 (0.2)6.6 (3.8)1-150 1-151
AST (U/l)47 (16)45 (11)234 (52)1-150 37 (4)34 (10)171 (28)1-150 1-151
ALT (U/l)33 (15)24 (5)118 (35)1-150 26 (4)25 (4)47 (15)1-150 1-151
AP (U/l)231 (41)288 (45)599 (71)1-150 261 (36)269 (49)515 (57)1-150
Portal pressure (mm Hg)7.4 (1.1)19.9 (2.1)1-150 18.9 (1.8)1-150 7.2 (0.5)18.7 (2.2)1-150 17.9 (1.3)1-150
  • AST, aspartate aminotransferase; ALT, alanine aminotransferase; AP, alkaline phosphatase.

  • 1-150 p<0.01 v SL;

  • 1-151 p<0.05v untreated ( no tungsten supplement).