Effect of dexamethasone (DEX) on interleukin (IL) 1β induced leucocyte extravasation into the rat peritoneal cavity
| Leucocytes | |||
|---|---|---|---|
| Treatment | Time (h) | 106 per rat | % |
| None | 0 | 0.97 (0.06) | 100 |
| IL-1β | 2 | 1.48 (0.27) | 152 |
| + DEX | 2 | 1.22 (0.17) | 126 |
| IL-1β | 4 | 3.10 (0.25)1-150 | 319 |
| + DEX | 4 | 1.10 (0.29)1-151 | 113 |
Rats were left untreated or injected intraperitoneally with 20 ng rat IL-1β. In some cases animals were pretreated with DEX (100 μg/kg subcutaneously) one hour prior to cytokine administration.
Data are mean (SEM); n=6 rats per group.
↵1-150 p<0.05 versus control group (time 0);
↵1-151 p<0.05 versus respective IL-1β group (time 4 h).