Peak serum values of mediators in various clinical complications in acute pancreatitis (median (interquartile range))
| IL-1β (pg/ml) | IL-1RA (U/ml) | sIL-2R (pg/ml) | IL-6 (ng/ml) | IL-8 (pg/ml) | IL-10 (U/ml) | |
|---|---|---|---|---|---|---|
| No sepsis (n= 40) | 2.93 (0.5–5.7) | 2751 (1717–6391) | 727.3 (448–1077) | 427 (223–1059 | 114 (54–706) | 6.7 (3.1–12.9) |
| Sepsis (n= 11) | 4.93 (4.1–8.25) | 3825 (3306–6585) | 1528.5 (792–2224) | 867 (524–1507) | 158 (121–390) | 29.97 (16.42–43.5) |
| p Value | NS | NS | 0.04 | NS | NS | 0.02 |
| No pulmonary dysfunction (n=33) | 2.8 (0.5–4.2) | 2751.5 (1639–4176) | 581.4 (428–776) | 295 (219–429) | 88.2 (41–1086) | 4.78 (3.1–9.8) |
| Pulmonary failure (n=18) | 7.0 (5.1–17) | 5495.5 (3265–8260) | 2224 (960–3205) | 1760 (989–2071) | 157 (95–337) | 31.4 (17.6–61.4) |
| p Value | 0.004 | NS | 0.001 | 0.0005 | NS | 0.0006 |
| No renal dysfunction (n=37) | 3.47 (2–5.1) | 3703 (2451–5453) | 700 (504–971) | 392 (232–693) | 86.2 (65–164) | 8.8 (4.4–16.8) |
| Renal failure (n=14) | 7.1 (5.9–10.4) | 8869 (3929–14508) | 3259 (2620–4261) | 1670 (1505–1780) | 155 (152–158) | 67.5 (40.2–97.4) |
| p Value | 0.03 | 0.03 | 0.001 | 0.003 | NS | 0.008 |
IL, interleukin; IL-1RA, interleukin 1β receptor antagonist; sIL-2R, soluble interleukin 2 receptor.