Effects of administration of anti-tumour necrosis factor α (TNF-α) antibodies on nitrite/nitrate concentrations in serum with D-galactosamine (D-GalN) and/or prostaglandin E1(PGE1) treatments
| Treatment | Nitrite/nitrate (μM) |
|---|---|
| Control | 17 (0.9)d |
| PGE1 | 29 (2.9)b |
| D-GalN | 18 (1.0)d |
| PGE1+D-GalN | 22 (1.5)c |
| Anti-TNF-α+control | 45 (8.5)a |
| Anti-TNF-α+PGE1 | 31 (7.3)ab |
| Anti-TNF-α+D-GalN | 17 (5.3)cd |
| Anti-TNF-α+PGE1+D-GalN | 30 (7.3)abc |
Administration of anti-TNF-α antibodies enhanced nitrite/nitrate concentrations in the control group.
Values are mean (SEM) (n=5).
Groups with different superscript letters are significantly different (p⩽0.05).