Outcome measure | Time (week) | Lam/interferon (n=68) | Interferon (n=64) | Lamivudine (n=80) |
HBeAg loss | 24 | 19 (62) | 11 (57) | 14 (70) |
52 | 35 (55) | 23 (56) | 23 (60) | |
64 | 33 (55) | 29 (48) | 21 (62) | |
HBV DNA loss | 24 | 84 (62) | 30 (57) | 64 (70) |
52 | 36 (55) | 29 (55) | 60 (60) | |
64 | 31 (55) | 29 (49) | 32 (63) | |
ALT normalisation | 24 | 34 (62) | 21 (58) | 51 (72) |
52 | 38 (55) | 29 (55) | 57 (58) | |
64 | 36 (50) | 32 (50) | 21 (63) |
HBeAg loss is defined as undetectable (AS×YM, Abbott); HBV DNA loss is defined as HBV DNA values below the cut off (3 pg/ml, Abbott HBV DNA test); ALT normalisation is defined as ⩽1.0×ULN. Number of patients is indicated in parentheses.