Table 1

Serum biochemical data in normal, cirrhotic, and fulminant hepatitis livers, before and after infusion of adenovirus

Adenovirus infusionNormalCirrhoticFulminant
AST (u/litre)
 Before68.8  (10.9)124.0  (33.40)3311.7  (1313.7)
 After156.1 (58.7)1-150 260.1 (91.2)1-150 159.3 (72.3)1-150
 NoneNDND177.9 (67.0)1-150
ALT (u/litre)
 Before24.3 (4.2)51.0 (16.1)4469.0 (1737.6)
 After30.7 (10.0)84.0 (25.8)1-150 47.3 (38.8)1-150
 NoneNDND87.0 (40.1)1-150
LDH (u/litre)
 Before724.8 (252.5)712.3 (281.3)9094.7 (2857.9)
 After2045.0 (331.9)1-150 1624.1 (528.7)1-150 1660.3 (836.7)1-150
 NoneNDND1441.3 (916.8)1-150

  • ↵1-150 Data are mean (SD) of eight animals.

  • ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase, all expressed as units per litre at 37°C.

  • *Significantly different (p<0.05) from before administration of adenovirus, using Welch's t test.

  • ND, not done.