Mucin genes and their location in the human gastrointestinal tract
| MUC gene | Chromosome | Mucin type | Major expression in normal gastrointestinal tract | |||
|---|---|---|---|---|---|---|
| MUC1 | 1q21 | Membrane | Salivary glands: acini | |||
| Oesophagus: surface stratified squamous epithelium, submucosal gland ducts | ||||||
| Stomach-fundus: surface epithelium, glands; body and antrum: surface foveolar cells, mucous neck cells | ||||||
| Small intestine: goblet cells and enterocytes in surface/villi and deep/crypts | ||||||
| Colorectum: goblet cells and colonocytes in surface/villi and deep/crypts | ||||||
| MUC2 | 11p15.5 | Secreted, gel forming | Small intestine: goblet cells in surface/villi and deep/crypts | |||
| Colon: goblet cells in surface/villi and deep/crypts | ||||||
| MUC3 | 7q22 | Membrane | Salivary glands: submaxillary gland acini | |||
| Stomach-body and antrum: surface foveolar cells | ||||||
| Small intestine: goblet cells and enterocytes in surface/villi | ||||||
| Colorectum: goblet cells and colonocytes in surface/villi | ||||||
| MUC4 | 3q29 | Membrane | Oesophagus: surface stratified squamous epithelium, submucosal gland ducts | |||
| Stomach-fundus: surface epithelium, glands; body and antrum: surface foveolar cells, mucous neck cells | ||||||
| Small intestine: goblet cells and enterocytes in surface/villi and deep/crypts | ||||||
| Colorectum: goblet cells and colonocytes in surface/villi and deep/crypts | ||||||
| MUC5AC | 11p15.5 | Secreted, gel forming | Stomach-fundus: surface epithelium; body and antrum: surface foveolar cells | |||
| MUC5B | 11p15.5 | Secreted, gel forming | Salivary glands: acini | |||
| Oesophagus: submucosal gland acini and ducts | ||||||
| Stomach-fundus: surface epithelium, | ||||||
| Colorectum: goblet cells in deep/crypts | ||||||
| MUC6 | 11p15.5 | Secreted, gel forming | Stomach-fundus: glands;body and antrum: mucous neck cells | |||
| Small intestine: duodenal Brunner's gland acini | ||||||
| MUC7 | 4q13-q21 | Secreted, non-gel forming | Salivary glands: acini | |||
| MUC8 | 12q24.3 | Secreted, gel forming? | Not expressed | |||
| MUC9 | 1p13. | Secreted, gel forming | Not expressed | |||
| MUC11 | 7q22 | Secreted, gel forming? | Small intestine | |||
| Colorectum | ||||||
| MUC12 | 7q22 | Membrane | Colorectum | |||