Clinical baseline characteristics of non-transplant cirrhotics with hepatorenal syndrome (HRS) (n=41)
| Total study cohort data | TIPS treated cohort data | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Total (n=41) | Non-TIPS (n=10) | TIPS (n=31) | p Value | HRS type I (n=21) | HRS type II (n=20) | p Value | HRS type I ( n=14) | HRS type II (n=17) | p Value | |
| Age (y) | 57 (11) | 50 (15) | 59 (9) | <0.05 | 60 (8) | 52 (12) | 0.02 | 56 (9) | 61 (8) | NS | |
| Aetiology of LC | |||||||||||
| Alcoholic | 31 | 6 | 25 | 18 | 13 | 12 | 13 | ||||
| Post-hepatitic | 8 | 4 | 4 | 3 | 5 | 2 | 2 | ||||
| Cryptogenic | 2 | 0 | 2 | NS | 0 | 2 | NS | 0 | 2 | NS | |
| Causes for transplant refusal | |||||||||||
| Active alcoholism | 26 | 6 | 20 | 13 | 13 | 9 | 11 | ||||
| Advanced age | 5 | 1 | 4 | 1 | 4 | 2 | 2 | ||||
| Advanced cachexia | 9 | 3 | 6 | 7 | 2 | 3 | 3 | ||||
| Recent cancer | 1 | 0 | 1 | NS | 0 | 1 | NS | 0 | 1 | NS | |
| Child-Pugh score | 10.4 (1.9) | 12.8 (1.0) | 9.5 (1.4) | <0.001 | 11.0 (2.1) | 9.7 (1.5) | 0.02 | 9.8 (1.5) | 9.3 (1.3) | NS | |
| Child-Pugh grade | |||||||||||
| A | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| B | 16 | 0 | 16 | 6 | 10 | 6 | 10 | ||||
| C | 25 | 10 | 15 | <0.01 | 15 | 10 | <0.05 | 8 | 7 | NS | |
| Bilirubin (mg/dl) | 6.8 (9.0) | 17.4 (12.0) | 3.1 (3.3) | <0.01 | 10.6 (11.7) | 2.7 (2.8) | <0.01 | 4.6 (4.4) | 1.8 (1.0) | 0.02 | |
| Albumin (g/dl) | 2.9 (0.5) | 2.7 (0.7) | 2.9 (0.5) | NS | 2.9 (0.5) | 2.8 (0.5) | NS | 3.1 (0.5) | 2.8 (0.4) | NS | |
| Prothrombin time (%) | 66 (24) | 40 (11) | 74 (22) | <0.001 | 54 (21) | 78 (22) | <0.001 | 64 (19) | 82 (21) | 0.02 | |
| Serum creatinine (mg/dl) | 2.8 (2.1) | 4.4 (2.1) | 2.3 (1.7) | <0.01 | 3.7 (1.4) | 1.6 (0.5) | <0.001 | 3.11 (2.2) | 1.44 (0.3) | 0.01 | |
| Serum urea (mg/dl) | 87 (67) | 147 (93) | 68 (42) | <0.05 | 99 (87) | 75 (34) | NS | 64 (50) | 72 (35) | NS | |
| Creatinine clearance (ml/min) | 16.0 (15) | 9.3 (12) | 18 (15) | NS | 5.8 (4.9) | 32.9 (15) | <0.001 | 6.4 (6) | 28.3 (14) | <0.001 | |
| Serum sodium (mmol/l) | 130 (6) | 128 (6) | 130 (6) | NS | 130 (6) | 130 (7) | NS | 130 (6) | 130 (7) | NS | |
| Sodium excretion (mmol/24 h) | 11 (21) | 8 (14) | 12 (16) | NS | 15 (18) | 8 (12) | NS | 13 (18) | 10 (12) | NS | |
| Urine volume (ml/24 h) | 481 (365) | 286 (268) | 544 (373) | <0.05 | 383 (414) | 584 (279) | NS | 449 (452) | 622 (284) | NS | |
p values were calculated from subgroup comparisons of clinical baseline characteristics.
To convert values for creatinine to μmol/l, multiply by 88.4; to convert values for urea to mmol/l, multiply by 0.167; to convert values for bilirubin to μmol/l, multiply by 17.1.
LC, liver cirrhosis.