Effect of IL-1α and IL-1ra on jejunal 3-O-methyl glucose transport
| Jms
(μEq/cm2/h) | Jsm
(μEq/cm2/h) | Jnet
(μEq/cm2/h) | PD (mV) | Isc
(μA/cm2) | G (mS/cm2) | |
| Basal period 1 | 0.80 (0.09) | 0.22 (0.02) | 0.58 (0.10) | 3.3 (0.2) | 38 (5) | 29 (3) |
| Control period 2 | 0.89 (0.08) | 0.27 (0.02) | 0.62 (0.08) | 3.0 (0.2) | 34 (5)1-a | 28 (3) |
| (n=8) | Δ=0.10 (0.04) | Δ=0.05 (0.03) | Δ=0.04 (0.04) | |||
| Basal | 0.74 (0.07) | 0.13 (0.01) | 0.62 (0.07) | 3.4 (0.2) | 34 (3) | 26 (2) |
| IL-1α (5 ng/ml) | 0.97 (0.11)1-a | 0.19 (0.01)1-a | 0.78 (0.1)1-a | 3.0 (0.2) | 30 (3) | 26 (2) |
| (n=5) | Δ=0.22 (0.05) | Δ=0.06 (0.01) | Δ=0.17 (0.05) | |||
| Basal | 0.87 (0.05) | 0.15 (0.01) | 0.72 (0.06) | 3.2 (0.2) | 42 (4) | 34 (4) |
| IL-1α (10 ng/ml) | 1.14 (0.06)1-b | 0.2 (0.03) | 0.95 (0.06)1-a | 2.8 (0.1)1-a | 40 (3) | 36 (4) |
| (n=5) | Δ=0.27 (0.04) | Δ=0.05 (0.02) | Δ=0.22 (0.06) | |||
| Basal | 0.88 (0.08) | 0.18 (0.03) | 0.70 (0.09) | 3.4 (0.3) | 40 (3) | 30 (2) |
| IL-1α (50 ng/ml) | 1.16 (0.14)1-a | 0.26 (0.02)1-a | 0.91 (0.13)1-a | 3.0 (0.3)1-b | 35 (2)1-b | 29 (2) |
| (n=6) | Δ=0.28 (0.08) | Δ=0.07 (0.02) | Δ=0.21 (0.07) | |||
| Basal | 0.78 (0.1) | 0.12 (0.01) | 0.66 (0.1) | 3.1 (0.3) | 34 (4) | 28 (3) |
| IL-1α (10 ng/ml)+ IL-1ra (100 ng/ml) | 0.91 (0.14) | 0.15 (0.02) | 0.77 (0.15) | 2.7 (0.2)1-a | 29 (4)1-a | 27 (3) |
| (n=5) | Δ=0.13 (0.06) | Δ=0.03 (0.01) | Δ=0.10 (0.06) | |||
| Basal | 0.79 (0.04) | 0.17 (0.01) | 0.62 (0.05) | 3.2 (0.4) | 35 (2) | 27 (4) |
| IL-1ra (100 ng/ml) | 0.89 (0.04) | 0.19 (0.03) | 0.70 (0.04) | 2.9 (0.1) | 31 (2) | 26 (2) |
| (n=4) | Δ=0.10 (0.01) | Δ=0.02 (0.03) | Δ=0.08 (0.03) |