Quantitative antagonism of isoprenaline relaxation of human circular and longitudinal (taenia) smooth muscle preparations by propranolol and CGP 12177
| pA2 | Slope | |
| Propranolol | ||
| Circular | 8.71 (0.27) | 0.88 (0.10) |
| Taenia | 8.51 (0.12) | 0.57 (0.03)2-160 |
| CGP 12177 | ||
| Circular | 10.3 (0.17) | 0.83 (0.05) |
| Taenia | 9.84 (0.22) | 0.47 (0.04)2-160 |
Values are mean (SEM).
pA2 values were calculated from linear regression of mean log values (Dr−1) against the negative log of antagonist concentrations (10−6 mol/l): propranolol, 0.01, 0.03, 0.1, 0.3, 1, 3, 10; CGP 12177, 0.001, 0.003, 0.01, 0.03, 0.1, 0.3, 1. An agonist concentration-response curve (n=4–10 preparations from different patients) was plotted for each antagonist concentration.
↵2-160 p < 0.01, slope different from unity.