Table 2

Effect of physiological (low dose, 0.4 pmol/kg/min) and supraphysiological (high dose, 1.2 pmol/kg/min) doses of GLP-1 on antral and duodenal motility with intraduodenal perfusion of saline or lipid (2.5 kcal/min, 2.5 ml/min)

Antral motilityDuodenal motility
Contractions
(No/60 minutes)		Motility index (mm Hg•s/60 minutes)Amplitude
(mm Hg)		Contractions
(No/60 minutes)		Motility index (mm Hg•s/60 minutes)Amplitude
(mm Hg)
Intraduodenal saline
Saline iv69.3  (9.9)18601  (5758)63.0  (7.5)183.7  (25.1)19502  (4321)39.5  (3.6)
 GLP-1 iv: low dose12.6 (2.8)2-150 1478 (564)2-150 31.1 (3.1)2-150 36.0 (14.7)2-150 3447 (1624)2-150 25.0 (2.5)2-150
 GLP-1 iv: high dose9.6 (2.8)2-150 957 (322)2-150 21.1 (3.1)2-150 2-152 16.6 (3.9)2-150 1119 (226)2-150 17.5 (1.9)2-150 2-152
Intraduodenal lipid
Saline iv24.3 (4.5)2-151 2-154 2749 (695)2-151 32.5 (3.1)2-151 85.4 (16.4)2-151 2-154 9545 (2891)2-151 2-154 32.9 (3.1)2-151 2-154
 GLP-1 iv: low dose12.1 (4.1)2-150 880 (351)2-150 23.6 (3.1)2-150 29.5 (5.8)2-150 2776 (890)2-150 26.0 (3.3)2-150
 GLP-1 iv: high dose9.2 (2.9)2-150 628 (249)2-150 23.0 (2.7)2-150 16.6 (5.9)2-150 2-152 1174 (499)2-150 2-152 19.2 (3.1)2-150 2-152
 Saline iv: recovery28.7 (7.5)2-152 2-153 3147 (785)2-152 2-153 34.7 (3.8)2-152 2-153 69.6 (21.2)2-152 2-153 8732 (3574)2-152 2-153 36.6 (4.5)2-152 2-153

  • Mean (SEM) of actual values during each 60 minute infusion period. Values for contractions and motility indices represent the sum of two antral and three duodenal side holes, respectively; n=11.

  • For the same intraduodenal perfusion:

  • ↵2-150 p<0.05v saline iv;

  • ↵2-152 p<0.05v low dose GLP-1;

  • ↵2-153 p<0.05v high dose GLP-1. For different intraduodenal perfusions:

  • ↵2-151 p<0.05 v saline iv/intraduodenal saline;

  • ↵2-154 p<0.05 v low dose GLP-1/intraduodenal saline.