Demographic features of the Crohn's disease study population stratified by ANCA and ASCA expression
| ASCA | ANCA | ||||||
|---|---|---|---|---|---|---|---|
| All CD | ASCA+ | ASCA− | pANCA+ | Other ANCA+ | ANCA− | ||
| n | 156 | 88 | 68 | 33 | 54 | 69 | |
| Sex (M:F) | 85:71 | 51:37 | 34:34 | 15:18 | 28:26 | 42:27 | |
| Age (y) | 41 (1) | 38 (1)1-150 | 44 (2) | 40 (2) | 42 (2) | 40 (2) | |
| Age at CD onset (y) | 25 (1) | 22 (1)1-150 | 29 (2) | 26 (2)1-160 | 27 (2)1-165 | 23 (1) | |
| Duration of disease (y) | 16 (1) | 17 (1)1-150 | 14 (1) | 14 (2)1-160 | 14 (1)1-165 | 17 (1) | |
| Jewish ancestry (%) | 64 (41%) | 40 (45%) | 24 (35%) | 16 (48%) | 22 (41%) | 26 (38%) | |
| Family history | |||||||
| IBD (%) | 48 (31%) | 28 (32%) | 20 (29%) | 10 (30%) | 16 (30%) | 22 (32%) | |
| CD (%) | 33 (21%) | 19 (22%) | 14 (21%) | 6 (18%) | 13 (24%) | 14 (20%) | |
| UC (%) | 17 (11%) | 9 (10%) | 8 (12%) | 2 (6%) | 7 (13%) | 8 (12%) | |
| Immunomodulatory therapy (%) | 126 (81%) | 77 (88%)1-150 | 49 (72%) | 27 (82%) | 39 (72%) | 60 (87%) | |
Values are mean (SEM) or number (%).
ASCA, anti-Saccharomyces cerevisiae antibody; pANCA, perinuclear antineutrophil cytoplasmic antibodies; CD, Crohn's disease; IBD, inflammatory bowel disease; UC, ulcerative colitis.
↵1-150 p t-test<0.0001, ASCA+ vASCA−;
↵1-160 p Fisher's LSD test from ANOVA <0.0001, pANCA+ vANCA−;
↵1-165 p Fisher's LSD test from ANOVA <0.0001, other ANCA+ v ANCA-.