Relationship between microsatellite instability status and mutations in coding region of hereditary non-polyposis colorectal cancer adenomas
| %MSI4-a | n | TGFβRII(A)104-b | IGF2R(G)84-c | BAX(G)84-d | hMSH3(A)8e | hMSH6(C)8f |
|---|---|---|---|---|---|---|
| <40 | 14 | 0 | 0 | 0 | 0 | 0 |
| 40–59 | 6 | 0 | 1 | 1 | 1 | 0 |
| 60–79 | 3 | 0 | 0 | 1 | 1 | 0 |
| 80+ | 7 | 1 | 1 | 0 | 1 | 44-g |
↵4-a Percentage of non-coding region markers with genetic alteration out of the informative markers;
↵4-b TGFβRII(A)10, poly(A)10 tract of TGFβ receptor type II gene;
↵4-c IGF2R(G)8, poly(G)8 tract of IGF receptor type 2 gene;
↵4-d BAX(G)8, poly(G)8 tract of BAX gene;ehMSH3(A)8, poly(A)8 tract of human MSH3 gene;
4-f hMSH6(C)8, poly(C)8 of human MSH6 gene.
↵4-g Fisher's exact test for %MSI of 40–79 and +80v the presence of mutation of hMSH6(C)8 was significant (p<0.02).