Table 2

Effects of non-steroidal anti-inflammatory drugs (NSAIDs) on azoxymethane (AOM) induced aberrant crypt foci (ACF) in rat colon

Group		Incidence^2-b		No of ACF/colon^2-c		No of foci containing
Group		Incidence^2-b		No of ACF/colon^2-c		1 crypt^2-c	2 crypts^2-c	3 crypts^2-c	⩾4 crypts^2-c
1. AOM alone	9/9	47.6 (5.2)	14.0 (4.9)	24.7 (4.2)	5.9 (1.8)	3.0 (2.0)
2. AOM+sulindac^2-a	7/7	23.4 (6.8)^e	8.4 (4.3)	10.4 (3.6)^e	3.4 (2.2)	1.1 (0.6)
3. AOM+etodolac^2-a	7/7	21.9 (4.3)^e	4.7 (1.8)^e	13.0 (3.2)^e	3.2 (1.0)^d	0.9 (0.6)^d
4. Sulindac alone^2-a	0/5	0	0	0	0	0
5. Etodolac alone^2-a	0/5	0	0	0	0	0
6. No treatment	0/8	0	0	0	0	0

↵2-a Each NSAID was given as 10 mg/kg.
↵2-b Number of rat colons with ACF/total number of colons scored.
↵2-c Mean (SD).
^{d, e}Significantly different from group 1 by Student'st test (^dp<0.05 and^ep<0.01).