Expression of COX-1 in intrahepatic cholangiocarcinoma and matched non-tumorous tissue
| Matched non-tumorous tissue | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case No | Differentiation2-150 | Cholangiocarcinoma cells | Bile duct cells | Hepatocytes | ||||||||
| Ratio of positive cells2-151 | I | P | Ratio of positive cells | I | P | Ratio of positive cells | I | P | ||||
| 8 | Well | 0 | − | − | na | na | na | 0 | − | − | ||
| 9 | Well | 0 | − | − | 0 | − | − | 3 | 1 | D | ||
| 10 | Well | 0 | − | − | na | na | na | na | na | na | ||
| 11 | Well | 1 | 2 | F | 0 | − | − | 0 | − | − | ||
| 12 | Well | 0 | − | − | na | na | na | na | na | na | ||
| 13 | Well | 0 | − | − | 0 | − | − | na | na | na | ||
| 14 | Well | 0 | − | − | 0 | − | − | 0 | − | − | ||
| 15 | Moderate | 0 | − | − | 0 | − | − | 3 | 1 | D | ||
| 16 | Moderate | 2 | 2 | D | na | na | na | 3 | 1 | D | ||
| 17 | Moderate | 1 | 2 | F | na | na | na | na | na | na | ||
| 18 | Moderate | 1 | 2 | S | 0 | − | − | 3 | 1 | D | ||
| 19 | Moderate | 0 | − | − | 0 | − | − | 3 | 1 | D | ||
| 20 | Moderate | 0 | − | − | 0 | − | − | 2 | 1 | D | ||
| 21 | Moderate | 1 | 2 | S | 0 | − | − | 0 | − | − | ||
| 22 | Moderate | 1 | 2 | F | 0 | − | − | 3 | 1 | D | ||
| 23 | Moderate | 1 | 2 | F | na | na | na | na | na | na | ||
| 24 | Moderate | 0 | − | − | 0 | − | − | 3 | 1 | D | ||
| 25 | Poor | 0 | − | − | 0 | − | − | 0 | − | − | ||
| 26 | Poor | 3 | 1 | D | 0 | − | − | 3 | 1 | D | ||
| 27 | Poor | 0 | − | − | 0 | − | − | 3 | 1 | D | ||
| 28 | Poor | 0 | − | − | 0 | − | − | na | na | na | ||
| 29 | Poor | 2 | 2 | D | na | na | na | 1 | 2 | F | ||
| 30 | Poor | 1 | 1 | S | 0 | − | − | 0 | − | − | ||
| 31 | Poor | 2 | 2 | D | 2 | 2 | F | na | na | na | ||
I, intensity; P, pattern; D, diffuse; F, focal; S, sporadic; na, not available.
↵2-150 Well differentiated cholangiocarcinoma: tumour cells are arranged to form well developed gland-like structures mainly lined by a single layer of epithelial cells with regular size and space and uniform nuclei with indistinct nucleoli; moderately differentiated cholangiocarcinoma: tumour cells are organised to form less well formed glandular structures which are often lined by stratified layers of epithelial cells with a higher degree of nuclear atypia; poorly differentiated cholangiocarcinoma: tumour cells rarely form glandular structures and their nuclei are arranged with an irregular spacing pattern and with markedly pleomorphic shapes and sizes. Tumour cells possess prominent nucleoli.
↵2-151 For definition see table 1.
−, no immunosignal.