Table 2

Whole colon and segmental indexes of epithelial cell proliferation in adenoma patients (n=15) and in controls (n=9)

PatientsControls
Labelling indexWhole colonRight colonLeft colonS-RWhole colonRight colonLeft colonS-R
Total labelling index (TLI) 8.2 (0.3)2-a  8.6 (0.9)b  9.2 (0.3)2-c  7.1 (0.4)d  5.3 (0.2) 5.6 (0.2) 4.5 (0.4) 5.8 (0.5)
Crypt compartment LI
 Compartment 117.2 (1.1)2-e 17.7 (1.2)17.7 (1.3)2-f 16.4 (2.7)12.2 (0.7)11.4 (2.2)11.8 (0.4)13.4 (0.9)
 Compartment 215.9 (1.4)g 15.3 (3.0)20.5 (1.1)h 12.6 (2.3) 9.3 (0.6) 8.2 (0.4) 8.1 (1.7)11.5 (0.1)
 Compartment 3 6.5 (0.7)i  9.6 (1.1)2-150  6.9 (1.5)l  3.5 (0.6) 3.8 (0.7) 7.8 (0.5)2-151  0.0 (0.0) 3.5 (0.1)2-152
 Compartments 4–5 0.6 (0.1)m  0.3 (0.1) 0.9 (0.3)n  0.5 (0.2) 0.05 (0.03) 0.0 (0.0) 0.0 (0.0) 0.1 (0.09)

  • Whole colon, mean of LIs for crypts in all three segments; S-R, sigmoid rectum.

  • Results expressed as mean (SEM).

  • ↵2-a p<0.0001 v TLI of whole colon of controls;

  • 2-b p<0.05 v TLI of right colon of controls;

  • ↵2-c p>0.005v TLI of left colon of controls;

  • 2-d p>0.05 v TLI of S-R of controls;

  • ↵2-e p<0.005 vcompartment 1 LI of whole colon of controls;

  • ↵2-f p< 0.01v compartment 1 LI of left colon of controls;

  • 2-g p<0.05 v compartment 2 LI of whole colon of controls;

  • hp<0.005v compartment 2 LI of left colon of controls;

  • ip< 0.05 vcompartment 3 LI of whole colon of controls;

  • lp<0.001v compartment 3 LI of left colon of controls;

  • mp<0.005 vcompartments 4–5 LI of whole colon of controls;

  • np<0.01v compartments 4–5 LI of left colon of controls (Mann-Whitney U test).

  • ↵2-150 p<0.05 v compartment 3 LI of S-R of patients;

  • ↵2-151 p<0.05 v compartment 3 LI of left colon and S-R of controls;

  • ↵2-152 p<0.05 vcompartment 3 LI of left colon of controls (Bonferroni test after one way ANOVA).